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Atypical presentation of primary cutaneous diffuse large B cell lymphoma on the leg
( Myong Il Bae ) , ( Tae In Kim ) , ( June Hyuck Yim ) , ( Ki Heon Jeong ) , ( Min Kyung Shin ) , ( Nack In Kim )
UCI I410-ECN-0102-2015-500-002016337
This article is 4 pages or less.

Primary cutaneous lymphomas are defined as lymphocytic neoplasias that present themselves clinically in the skin without extracutaneous disease at diagnosis and up to 6 months. The skin lesion of primary cutaneous B-cell lymphomas have variable clinical, histopathologic, and immunologic phenotypes. Primary cutaneous lymphomas often show a completely different clinical behavior and prognosis than histologically similar systemic lymphomas, which involve the skin secondarily. A 50-year-old man presented with solitary 3x1 cm sized cresent-shape well demarcated erythematous plaque with tingling sensation on the right lower leg. The skin lesion is gradually increasing from 3 month ago and severe pain was accompanied. Histopathologic findings shows dense infiltration of lymphocyte with atypical features in dermis. Immunohistochemical finding shows positive for CD3, CD20 and BCL-2 but negative for CD 56. Laboratory test was negative result in EBV and normal range of CD4 and CD8 cells. Computed tomography imaging of the chest, abdomen, and pelvis failed to show an associated systemic lymphoma. So he was referred to hematooncology department to further evaluation and to receive R-CHOP (rituximab, cyclophosphamide, hydroxydaunorubicin, Oncovin and prednisolone) which is considered to be the first line of treatment for these lymphomas. We report a case of atypical presentation of cutaneous diffuse large B cell lymphoma occurring on the leg.

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