Molluscum contagiosum (MC) is a common self-limiting skin infection due to the molluscum contagiosum virus(MCV). Clinically, MC usually presents as multiple, translucent, often umbilicated papules with a shiny surface measuring up to 5 mm. Rarely, MCV infection is found in an epidermal cyst (EC) in the absence of typical presentation of the MC. It has been proposed that MC infection of an EC may be due to coinoculation of MCV at the time of the formation of the cyst or invasion of a preexisting EC by MCV via the ostium that connects the epidermis with the underlying EC. A 41-year old man presented with asymptomatic, solitary, 0.8cm-sized, verrucous, pinkish mass on the upper back for several months. Clinical impressions were wart. However, pathological examination revealed true epidermal cyst containing molluscum bodies throughout the cyst wall and laminated keratotic material within the cyst itself. The lesion was clearly removed with electrodessication and curettage. In previous reports, only a few cases were found in adults, and most cases were presented with the flesh-colored or erythematous nodule or cyst. We herein report a case of molluscum contagiosum occurring in an epidermal cyst presenting atypical clinical manifestations.