Desmoplastic nevus (DN) is a rare benign melanocytic proliferation which was first described by Reed et al.Clinically, DN usually presents as a small, flesh-colored or erythematous or slightly pigmented papule or nodule ranging from 2mm to 1cm in size. Its diagnosis is primarily based onhistopathologic features characterizedby intradermal growth pattern composed of large spindle or epithelioid nevus cells embedded within a fibrotic stroma, sparse or no melanin pigment, no junctional activity and rare mitotic figures. And immunohistochemistry can also aid differential diagnosis of DN with other dermal proliferative diseases. A 38-year-old Caucasian woman presented with 6mm sized slightly pigmented papule of unknown onset which was located on her left dorsum of hand. Punch biopsy was done and spindle to oval cell proliferations with scanty pigmentation were seen within surrounding dense collagenous dermal stroma. And the specimen was focal S-100 positive, Melan-A positive, focal HMB-45 positive and 1% positive in Ki-67. Based on abovementioned findings, the lesion was diagnosed as desmoplastic nevus. Dermatologists should be aware of this entity, because its differential diagnosis from other diseases including desmoplastic melanoma is very important but often difficult owing to their similarity in cellular and stromal components.Therefore, we report a case of DN for educational purposes.