Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. MF is believed to result from chronic antigenic stimulation that leads to uncontrolledclonal expansion and the accumulation of T cell helper memory cells in the skin. Locoregional radiotherapy is the most reliable and rapid method of inducing a remission of solitary or localized lesion. For such patients with “curative” intent, radiation dose of approximately 30-36 Gy is widely used as in cases of other low-grade lymphomas. Fractionated doses can provide local control while minimizing the toxicity to the surrounding tissue. A 66-year-old woman presented with multiple patches like cigarette paper (>10% BSA) was diagnosed MF (IB, T2N0M0) by histopathologic finding and staging work-up. She was treated by locoregional radiotherapy with fractionated doses (200mGy x 16 times, total 32Gy). She achieved complete response and showed no recurrence for 36 months follow-up. Other 46-year-old woman presented with 6 x 3 cm sized solitary erythematous plaque on her Rt. cheek was diagnosed MF (IA,T1N0M0) by histopathologic finding and staging work-up and treated by locoregional radiotherapy with fractionated doses (200mGy x 16 times. Total 32Gy). She achieved complete response and showed no recurrence for 48 months follow-up. Herein, we report two cases of MF successfully treated by fractionated locoregional radiotherapy.