Vestibular papillomatosis(VP) is a benign condition of the female genitalia, which is characterized by multiple, filiform projections on the vestibular epithelium1. In the past, the pathogenesis of VP was considered to be related to human papillomavirus(HPV) infection, but currently, most of the authors believe that VP is a normal vulvar anatomical condition and is not related to HPV. A 21-year-old female was referred to our dermatologic clinic from the OBGYN clinic of the other hospital for the evaluation of multiple papular lesions on the vulva. At an OBGYN clinic, she was diagnosed as condyloma acuminata, and the lesions were surgically excised during ovarian cystectomy. After excision, the remaining lesions were treated unsuccessfully with topical imiquimod. Physical examination revealed symmetrically distributed, asymptomatic, multiple, papular projections on the inner labia minora. Histopathologic examination revealed a polypoid growth of a normal epithelium with a fibrovascular core and dilated capillaries. Both immunohistochemical staining and polymerase chain reaction for HPV were negative. The findings were consistent with the diagnosis of VP. Therefore, we report a typical case of VP to prevent unnecessary treatment and patient discomfort, and to improve the recognition of this disease condition.