Reticular erythematous mucinosis (REM) is a rare cutaneous condition that presents erythematous macules and papules coalescing into reticulate plaques usually on the midline. Due to its rarity and the diverse presentation, it may be easily misdiagnosed. We report a case of REM that was misdiagnosed as prurigo nodularis. A 55-year-old male with history of atopic dermatitis visited with a 3-year history of various sized erythematous papules on his arms and trunk. He was treated previously at other clinics under impressions of prurigo nodularis, erythema multiforme or eczema. Biopsy was done, which revealed superficial and deep perivenular and periadnexal lymphocytic infiltration and increased mucin deposit in the dermis, suggesting REM. He showed good response to steroids but his symptoms easily recurred after discontinuing steroids. Hydroxychloroquine was added with cyclosporine, in which the symptoms gradually stabilized. REM is a rare dermatologic disease and can present with diverse cutaneous manifestations, sometimes leading to misdiagnosis. It is important to know the variability of REM to be able to make the correct diagnosis.