Fault Tree Analysis to predict the lifetime in the design process of LNG compressor is considered. Fault Trees for P & ID of the compressor are created. Individual components that comprise the compressor are configured with the basic event. The failure rates in the PDS and OREDA are applied. As results, the system failure rate and the reliability over time are obtained. Further, the power transmission and the shaft seal system is confirmed to confidentially importantly contribute to the overall lifetime of the system. These techniques will help to improve the reliability of design of large scale machinery such as a plant.