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화학물질 관리 연구-1. 산업안전보건법상 관리 화학물질의 특성과 노출기준 비교
Study on the Chemical Management - 1. Chemical Characteristics and Occupational Exposure Limits under Occupational Safety and Health Act of Korea
박지훈 ( Ji Hoon Park ) , 함승헌 ( Seung Hon Ham ) , 김선주 ( Sun Ju Kim ) , 이권섭 ( Kwon Seob Lee ) , 하권철 ( Kwon Chul Ha ) , 박동욱 ( Dong Uk Park ) , 윤충식 ( Chung Sik Yoon )
UCI I410-ECN-0102-2015-500-002060633

Objectives: This study aims to compare the physicochemical characteristics, toxicological data with Occupational Exposure Limits (OELs) of chemicals under the Occupational Safety and Health Act(OSHA) regulated by the Ministry of Employment and Labor of Korea. Methods: Information on chemicals which have OELs on physicochemical characteristics and toxicological data was collected using Material Safety Data Sheet(MSDS) from Korea Occupational Safety and Health Agency(KOSHA) and the Korea Information System for Chemical Safety Management(KISChem) in 2014. Statistical analyses including correlation and simple regression were performed to compare the OELs with chemical characteristics including molecular weight, boiling point, odor threshold, vapor pressure, vapor density, solubility and octanol-water partition coefficient(OWPC) and toxicological data such as median lethal dose(LD50) and median lethal concentration(LC50). Results: A total of 656 chemicals have OELs under OSHA in Korea. The numbers of chemicals which have eight-hour time weighted average(TWA) and short term exposure limits(STEL) are 618 and 190, respectively. TWA was significantly correlated with boiling point and STEL was only correlated with vapor pressure among physicochemical characteristics. Solubility and OWPC between “skin” and “no skin” substances which indicate skin penetration were not significantly different. Both LD50 and LC50 were correlated with TWA, while the LC50 was not with STEL. As health indicators, health rating and Emergency Response Planning Guidelines(ERPG) rating as recommended by the National Fire Protection Association(NFPA) and American Industrial Hygiene Association(AIHA) were associated with OELs and reflect the chemical hazards. Conclusions: We found relationships between OEL and chemical information including physicochemical characteristics and toxicological data. The study has an important meaning for understanding present regulatory OELs.

I. 서 론
Ⅱ. 연구방법
Ⅲ. 결 과
Ⅳ. 고 찰
Ⅴ. 결 론
감사의 글
References
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