Objective: In severe multiple trauma patients, physicians check computed tomography (CT) to identify the occult injuries and intravenous (IV) contrast CT is often used. However, the contrast is known potentially nephrotoxic. So we measured the incidence and risk factors for contrast-induced nephropathy (CIN) in multiple trauma patients. Methods: A retrospective review was performed on 248 patients who were by activated trauma team between June 2012 and July 2014. Exclusion criteria were underlying renal failure, no IV contrast CT checked, no creatinine (Cr) level follow up. We examined age, gender, trauma mechanism, initial vital sign, Glasgow coma scale (GCS), initial Cr level, within 72hr Cr follow up level, IV contrast CT number, injury severity score (ISS), and treatment results. CIN was defined as a 25% relative or 0.5mg/dL absolute increase in serum Cr within 72hr of presentation. Results: 143 patients were included in this study. CIN happened in 12 patients (8.4%). Injury severity were significantly associated with CIN (ISS>16, p=0.003; GCS≤8, p<0.001; death, p<0.001). Initial Cr level, elderly patients (age>65) and initial low systolic blood pressure (<90mmHg) were not statistically significant (p=0.096, 0.176, 0.402, respectively). The number of IV contrast CT was also not associated CIN occurrence (p=0.331). Conclusions: We found a 8.4% incidence of CIN in multiple trauma patients exposed to IV contrast. More severely injured patients have more chance to develop CIN. The number of IV contrast, age, initial systolic BP and initial Cr level were not associated with CIN.