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ELSEVIER : Design, synthesis and docking study of 5-(substitutedbenzylidene)thiazolidine-2,4-dione derivatives as inhibitors of protein tyrosine phosphatase 1B
( Zeng Tao Wang ) , ( Zhi Guo Liu ) , ( Woo Jung Lee ) , ( Su Nam Kim ) , ( Goo Yoon ) , ( Seung Hoon Cheon )
UCI I410-ECN-0102-2015-500-002074811
This article is 4 pages or less.

A series of novel 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives was designed, and synthesized based on our previous studies. Also their activities were evaluated as competitive inhibitors of protein tyrosine phosphatase 1B (PTP1B). Compounds 6d-6g, 7b. 7c. 7e. 7j, 7k. 7m, 14b and 14e-4f showed potent inhibitory effects against PTP1 B. and compound 7e. the most potent among the series, had an IC50 of 4.6 uM. Also a Surflex-Dock docking model of7e was studied. Compound 7e showed a negative binding energy of -7.35 kcal/mol and a high affinity to PTP1B residues (Gly220. Ala217. Arg221. Asp181, Ser216, Cys215. Phe182. Gln262 and lIe219) in the active sites, indicating that it may stabilize the open form and generate tighter binding to the catalytic sites of PTP1 B. ⓒ 2014 Elsevier Ltd. All rights reserved.

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