닫기
18.97.9.173
18.97.9.173
close menu
Accredited
전기방사를 이용한 경피 약물 전달 체계용 알지네이트 웹 제조
Preparation of Electrospun Alginate Webs for Transdermal Drug Delivery Systems
구민경 ( Min Kyung Ku ) , 김창현 ( Chang Hyun Kim ) , 김형섭 ( Hyung Sup Kim )
UCI I410-ECN-0102-2015-500-002119251
* This article cannot be purchased.

In this study, alginate was electrospun for transdermal drug delivery systems. The spinnability of alginate was improved by the reduction of intra-molecular hydrogen bonding using glycerol. The prepared alginate solutions were electrospun and coagulated in CaCl2 aqueous solution for improved dimensional stability. To observe release ability, the electrospun alginate web was immersed in phosphate buffered saline (PBS) solution. Although 60% of dextran (drug model) was released from the prepared web within 30 minutes, the remaining drug was released continuously over 3 days. The results indicated that the prepared alginate web could be used as a transdermal drug delivery system.

[자료제공 : 네이버학술정보]
×