Background: There is a growing interest in the association between chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC). However, to the best of our knowledge, there are no previous studies to investigate the impact of COPD on the patients with small cell lung cancer (SCLC). The aim of this study is to compare the mortality and clinical characteristics of patient with SCLC according to the presence of COPD. Methods: We reviewed medical records of 110 patients with SCLC who had started chemotherapy at Gyeongsang National University Hospital from July 2006 to October 2013. The clinical characteristics between COPD and non-COPD groups were compared, and the impact of coexisting COPD on survival of patients with SCLC was assessed. Results: Of all 110 patients with SCLC, COPD was present in 57 patients (51.8%). There were no differences in age, sex, body mass index, smoking status, Eastern Cooperative Oncology Group Performance Status (ECOG PS), stage of SCLC, and comorbidities between COPD and non-COPD groups. More patients with COPD had a higher modified Medical Research Council scale, but other symptoms at presentation were comparable. The mean overall survival time of patients with COPD was shorter (14.7 ± 12.8 months) than that of patients without COPD (17.7 ± 16.6 months), which was not statistically significant (log-rank test, p=0.289). After multivariate analysis, ECOG PS = 2 and extensive stage of SCLC were independent risk factors for shorter survival, but coexisting COPD was not predictor of survival. Conclusions: COPD present over half of the patients with SCLC. But coexisting COPD doesn’t influence on the mortality of the patients with SCLC in this study.