Optimization of self-microemulsifying drug delivery system for telmisartan using Box-Behnken design and desirability function

Dong Won Lee; Jong Oh Kim; Jeong Hwan Kim; Nirmal Marasini; Bong Kyu Yoo; Chul Soon Yong; Bijay Kumar Poudel; Thiruganesh Ramasamy; Han Gon Choi; Hyuk Jun Cho

영남대학교 약품개발연구소 약품개발연구소 연구업적집 Optimization of self-microemulsifying drug delivery system for telmisartan using Box-Behnken design and desirability function

Optimization of self-microemulsifying drug delivery system for telmisartan using Box-Behnken design and desirability function

( Hyuk Jun Cho ) , ( Dong Won Lee ) , ( Nirmal Marasini ) , ( Bijay Kumar Poudel ) , ( Jeong Hwan Kim ) , ( Thiruganesh Ramasamy ) , ( Bong Kyu Yoo ) , ( Han Gon Choi ) , ( Chul Soon Yong ) , ( Jong Oh Kim )

영남대학교 약품개발연구소 2014.09

약품개발연구소 연구업적집 24권 48-48(1pages)

UCI I410-ECN-0102-2015-500-002240195

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초록

Objectives: To develop and optimize the novel self-microemulsifying drug delivery system (SMEDDS) formulation for enhanced water solubility and bioavailability of telmisartan (TMS) using the Box-Behnken design (BBD) and desirability function. Method: TMS-SMEDDS formulation consisted of the mixture of oil (Peceol), surfactant (Labrasol), co-surfactant (Transcutol), TMS and triethanolamine. A three-level BBD was applied to explore the main effect, interaction effect and quadratic effect of three independent variables, including the amount of Peceol (X1), Labrasol (X2) and Transcutol (X3). Determined conditions were 20

키워드

bioavailability

Box-Behnken design

optimization

self-microemulsifying drug delivery system

teimisartan

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