Life Science : 2,4-Diaryl-5,6-dihydro-1,10-phenathroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives for topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study

Pritam Thapa; Radha Karki; Won Jea Cho; Pil Hoon Park; Eung Seok Lee; Young Hwa Na; Young Joo Kwon; Kyung Hwa Leon; Han Young Yoo; Eun Youing Lee

영남대학교 약품개발연구소 약품개발연구소 연구업적집 Life Science : 2,4-Diaryl-5,6-dihydro-1,10-phenathroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives for topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study

Life Science : 2,4-Diaryl-5,6-dihydro-1,10-phenathroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives for topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study

( Pritam Thapa ) , ( Radha Karki ) , ( Han Young Yoo ) , ( Pil Hoon Park ) , ( Eun Youing Lee ) , ( Kyung Hwa Leon ) , ( Young Hwa Na ) , ( Won Jea Cho ) , ( Young Joo Kwon ) , ( Eung Seok Lee )

영남대학교 약품개발연구소 2012.09

약품개발연구소 연구업적집 22권 88-88(1pages)

UCI I410-ECN-0102-2015-500-002238491

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초록

Designed and synthesized thirty-two 2,4-diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives as rigid analogs of 2,4,6-trisubstituted pyridines were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Structure-activity relationship study showed that [2,2`;6`,2"]-terpyridine skeleton is important for the cytotoxicity against several human cancer cell lines. ⓒ 2011 Elsevier Lnc. All rights reserved.

키워드

Topoisonerase I and II

Cytotoxicity

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