Case Description: We experienced a case of metachronous four primary malignancies. The patient was 76-year-old man with mild wall thickening of GB (gall bladder) fundus and he had laparoscopic cholecystectomy and it revealed adenocarcinoma with invasion of lamina propria of GB. On Regular follow up of abdominal CT (computerized tomography) after 7 months of his cholecystectomy, his prostate was enlarged and hypervascular and the PSA (prostate specifi c antigen) level was high up to 119.9 ng/dL. He had hormonal therapy with goserelin acetate and leuprorelin acetate. 3 years after the diagnosis of his prostate cancer, multiple colon polyps were noticed at his colonoscopy for screening of outside clinic. He came to our hospital and had polypectomy. One of them on his sigmoid colon included focal intramucosal carcinoma, and others were tubular adenoma with low grade dysplasia. He got esophagogastroduodenoscopy and ulcerofungated mass was seen on greater curvature of distal antrum, which is suggesting malignancy. Biopsy showed some atypical glands, and distal gastrectomy was done. It was early gastric cancer of moderately differentiated adenocarcinoma with submucosal invasion and no involvement of lymph node and another organ (stage IA). He underwent no adjuvant therapy and is has been on regular follow up till this time.