Background: Endemicity of dengue infection is still an important in Indonesia. The hallmark of dengue infection is the posibility to progress to fatal disease. Dengue viral load has some role in the pathogenesis and acute clinical manifestation of dengue. The aim of study was to describe dengue viral load profi le in patients with dengue infection. Methods: This study design was cross-sectional study and conducted from January 2012 to November 2013. The subjects were dengue patients with 10 years-old of age or above, with fever on day-1 or day-2, suspected dengue infection according to WHO criteria, showed positive result either by NS-1, and or IgM - IgG. Complete blood count, clinical chemistry, and dengue viral load were performed on the fi rst day of admission. Correlations were analyzed with Spearman test. Results: We recruited 100 subjects with positive result either by Dengue NS-1, and or IgM - IgG, and positive viral load. The results were: fever 38±1.03℃, hemoglobin 13.57±1.45 g/dL, hematocrite 39.44±4.16 %, leucocyte 3.82x10³ cells/mm3, thrombocyte 98 (min-max 19-312)x10³ cells/mm3, dengue viral load 423 (min-max 1-41.7x106) copies. The clinical diagnosis were dengue fever, DHF grade I, and DHF grade II; with proportions: 52.5%, 42.6% and 4%, respectively. There were no correlation between dengue viral load with body temperature, hemoglobin, leucocyte, or thrombocyte level. There were signifi cant weak correlation between dengue viral load with thrombocytopenia <0.05). Conclusions: We reported signifi cant weak correlation between viral load with thrombocytopenia, and signifi cant weak negative correlation between dengue viral load with hemoconcentration, hematocrit and severity grading of dengue infection.