Background: The clinical outcome of the malignant lymphoma improved and longterm survivor increased. In addition, the improvement of the examination technology and available PET/CT, screening ability rose, multiple neoplasms increased drastically last decade. We reviewed multiple neoplasms including the ML which accounted for a major ratio in hematological malignancies. Methods: We were approved privacy policy by the Ethical Review Board. Between January 1988 and December 2013, we reviewed multiple neoplasms including hematological malignancies. The diagnosis of the multiple neoplasms depends on a criteria of Warren & Gates. The defi nition of metachronous type and synchronous type is 6 months interval. Results: During the studied period, 285 cases became the subject of the examination. The multiple neoplasms including the ML was 161 cases in that. Median age was 70 years, male/female ratio was 101/60, double neoplasms were 135 cases, triple neoplasms 24 cases, quadple neoplasms 2 cases. The type of multiple neoplasms, metachrounaous type, synchronous type, were 120 cases, 41 cases respectively. In metachronous double type, all cases were102, and median time of interval was 59 months. The Consist of malignant neoplasms, gastric cancer 39 cases, colon cancer 26 cases, lung cancer 24 cases, hepatocellular carcinoma 13 cases, breast cancer 13 cases, prostate carcinoma 10 cases, and 18 kind of diagnosis 64 cases. On the other hand, kind of malignant lymphoma, Hodgkin`s lymphoma 7 cases, non-Hodgkin`s lymphoma 153 cases, adult T cell lymphoma 1 case. Median overall survival time was 33 months. About double neoplasms, median overall survival time between metachronous and synchronous type, there is signifi cance difference. Conclusions: In metachronous double type, all cases were102, 41 cases out of 102 cases were diagnosed within 5 years. We can discover metachronous multiple neoplasms by serial observations of fi ve years from an initial diagnosis.