Introduction: This case report presents a rare case of myopathy due to intermittent dosing of colchicine, which was proven on electromyography. Symptoms resolved after cessation of colchicine with improvement in renal and liver functions. Case Report: A 66 year old Chinese gentleman, with background history of hypertension on olmesartan and chronic gout on intermittent dosing of colchicine, presented with acute weakness of bilateral lower limbs for investigation. He was noted to have acute kidney injury with raised creatinine kinase (CK) level and deranged liver enzyme levels. Differential diagnoses included fi rst presentation of polymyositis, Guillain Barre syndrome, rhabdomyolysis or myopathy. Progress: Nerve conduction studies and electromyography were performed, revealing characteristic changes of acute colchicine induced myopathy; namely resting membrane instability, positive sharp waves and fi brillations in affected proximal muscles. Cessation of colchicine led to improvement in renal and liver function as well as resolution of symptoms. Discussion: This case highlights the pharmacokinetics and metabolism of colchicine as well as its clinical signs and symptoms of varying degrees of toxicity. It is vital that patients on colchicine should be adequately eduated on the side effects of colchicine and be monitored for symptoms of toxicity. Creatinine kinase should be measured when myotoxicity is suspected.