Background: This study aims to investigate serum amylin levels and its association in type 2 diabetes mellitus patients without cardiac diseases. Methods: The study included 51, voluntary normotensive patients with type 2 diabetes mellitus (T2DM), which were eighteen or more aged and didn`t have coronary artery disease or structural heart diseases. All patients underwent echocardiography the day blood samples were drown for testing amylin levels and routine biochemistry. The continuous variables were compared by using the Mann Whitney U test or Kruskall Wallis test and student t-test. Results: The mean age of participitants was 48±12 years. The mean amylin levels was 1117±899 pg/mL and the mean myocardial performance index (MPI) was 0,36±0,8. It was found a statistically signifi cant positive correlation between serum amylin levels and myocardial performance index (r=0,443, p<0,05). The mean right carotis intima media thickness was 0,47±1,1 mm and the mean left carotis intima media thickness was 0,48±1,1 mm. There was a positive correlation between serum amylin levels and carotis intima media thickness(r=0,295, p<0,05). There was a statistically signifi cant negative correlation between serum amylin levels and age (r=-0,454, p<0,05) Conclusions: In our study, it was found that serum amylin levels may be linked with pathophysiological process in patients with T2DM and presence of their cardiovascular complications.