Background: Adiponectin and high sensitivity C-Reactive Protein play an important role in the pathogenesis of atherosclerosis. In this subgroup of InaDOCAR Prevent study, we determine the usefulness of anti-infl ammatory index in predicting vascular conditions Methods: 106 men age 40-60 years participated in the study. Routine physical examinations, adiponectin and hsCRP were measured. Anti-infl ammatory index is defi ned as the ratio of total adiponectin level and hsCRP. Considered as high, moderate, low vascular disturbance/ complications if the ratio is < 2, 2-8, and >8 respectively. All participants have physical exercise; for prediabetes and diabetes participants consume routine medication Results: From 2005 participants were followed up to 2006, 2008, and 2010. In 2005, of 33 diabetic patients, the AI index of <2, 2-8, and >8 were 28 (85%), 4 (12%), and 1 (3%) respectively. Of 65 prediabetic patients, the AI index were 33 (51%), 30 (46%), and 2 (3%) respectively. Of 62 Normo glycemia patients, the AI index were 16 (26%), 21 (34%), and 25 (40%) respectively. In 2006, of the 33 diabetic patients, the AI index of <2, 2-8, and >8 were 26 (79%), 6 (18%), and 1 (3%) respectively. Of 60 prediabetic patients, the AI index were 32 (53%), 26 (43%), and 2 (3%) respectively. Of 67 Normo glycemia patients, the AI index were 12 (18%), 24 (36%), and 31 (46%) respectively. In 2010, of the 25 diabetic patients, the AI index of <2, 2-8, and >8 were 18 (72%), 6 (24%), and 1 (4%) respectively. 42 prediabetic, AI index 48%, 43%, 10% respectively. Of 93 Normo glycemia patients, AI index 9%, 40%, 52% respectively Conclusions: This study shows that Anti-infl ammatory Index can be used as an indicator for vascular disturbance in normo glycemia, prediabetic, and diabetic patients.