미만성 폐출혈이 발생한 중증 루푸스 환자에서 고용량의 스테로이드 충격 요법에 치료 반응이 없어, rituximab 사용하여 호전된 증례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다

Rituximab is a chimeric murine-human monoclonal antibody that is directed against the specific B-cell CD20 antigen, which has recently been successfully used in active or refractory systemic lupus erythematosus (SLE) manifestations, such as nephritis, thrombocytopenia, and vasculitis. We report a case of a 25-year-old woman diagnosed with diffuse alveolar hemorrhage of SLE refractory to steroid pulse therapy. The patient was treated successfully with rituximab as a part of the immunosuppressive regimen.