Objectives: This study was carried out to investigate neuro-protective effects of Hwangryunhaedok-Tang Gamibang(Huanglianjiedu-Tang Jiaweifang), that consisted in Hwangryunhaedok-Tang, Uwhangchungsinwon(Niuhuangqingxinyuan), and other neuro-protective herbs. Methods: A 3-week longitudinal evaluation of a herbal formula in 13 subacute stage cerebral infarction patient. Mean velocity and pulsatility index(PI) of cerebral blood flow was measured in middle cerebral artery using transcranial doppler ultrasonograpy(TCD). Total cholesterol, total lipid, tri-glyceride, HDL-cholesterol, and LDL-cholesterol were measured after medication. For evaluting functional improvement, NIHSS and MBI also measured. And we compared sample and control group. Results: There was significant improvement of cerebral blood flow and lipid profile(LDL, HDL) in sample group. And there were significant functional improvement by NIHSS and MBI in each group, but compared two group, no significant difference was found statistically. Conclusions: On this results, Hwangryunhaedok-Tang Gamibang(Huanglianjiedu-Tang Jiaweifang) has neuro-protective effect and anti-hyperlipidemic effect.