Objectives: Stroke and myocardial infarction are the second and third highest causes of death in South Korea, respectively, and asthma is an inflammatory allergic disease that costs 4 trillion won annually to manage both directly and indirectly. Thus, this study was conducted to see if asthma is correlated with stroke and myocardial infarction. Methods: The subjects of this study were adults aged over 19 in 2009, of whom 4,452 people had stroke and 2,464, myocardial infarction. The investigation was done by analyzing the age, gender, education level, obesity, smoking and other diseases of the subjects, after which a logistic regression analysis was conducted to determine if there was a relation with asthma. Results: Among the stroke patients, there was a significant difference in the prevalence according to their gender, age, level of obesity, education level and smoking history. The percentage of asthma patients with stroke was 4.1%, which shows a significant difference. As for myocardial infarction, there was a significant difference in the prevalence when the patients were older, men, with a lower education level and were non-smokers. The percentage of asthma patients with myocardial infarction was 2.9%. The incidence of hypertension was 3.488 times higher in the stroke patients and 1.934 times higher in the myocardial infarction patients; of diabetes, 1.661 times higher in the stroke patients and 1.891 times higher in the myocardial infarction patients; and of hyperlipidemia, 1.569 times higher in the stroke patients and 2.899 times higher in the myocardial infarction patients. The prevalence of myocardial infarction was 2.575 times higher in the stroke group, and the prevalence of stroke was 2.470 times higher in the myocardial infarction group. In the asthma patients, the prevalence of stroke was 1.232 higher, which is 1.630 times higher than in the myocardial infarction group. Conclusion: The prevalence of asthma was 1.2 times higher in the stroke patients and 1.6 times higher in the myocardial infarction patients. Thus, asthma showed a significant correlation with stroke and myocardial infarction. However, because this study is a cross-sectional study that used questionnaires, we propose a prospective study to further investigate this relation.