Rheumatoid arthritis (RA) is a progressive form of arthritis that has devastating effects on joints and general health. It is classified as an auto-immune disease, because this disease is caused by the body`s own immune system acting against the body itself. Symptoms include painful, stiff, swollen joints, fever, fatigue, and loss of appetite In recent years, there has become clear that early suppression of RA disease activity is important in preventing progressive joint destruction and functional decline. There has been a complete remodeling of the traditional “therapeutic pyramid” by rheumatologists, who now treat RA earlier and more aggressively than ever before, using combinations of classic disease-modifying antirheumatic drugs (DMARDs), nonsteroidal anti-inflammatory drugs (NSAIDs), or new drugs. Although a cure remains incompletely, remission is an approachable goal.