Purpose: Radiotherapy (RT) is usually administered to the central airway in patients with unresectable adenoid cystic carcinoma (ACC). The purpose of this study was to investigate the incidence, characteristics, and outcomes of bronchoscopic intervention in patients with ACC who developed fibrotic airway stenosis following RT. Methods and Materials: Forty-seven patients with ACC, who underwent RT of the tracheobronchial tree from 1995 to 2011, were reviewed retrospectively. Fibrotic airway stenoses were diagnosed using three-dimensional computed tomography, flexible bronchoscopy, or both. Results: Eleven (23%) of the 47 patients with ACC suffered fibrotic airway stenosis following RT and received bronchoscopic intervention. Bronchoscopic intervention provided both immediate symptomatic relief and improvement of lung function in all patients, and no procedure-related death or immediate major complication such as pneumomediastinum, pneumothorax, pneumonia, or massive bleeding was observed. Insertion of a straight silicone stent was required in 10 patients (91%), and 4 (36%) eventually received Y-shaped silicone stents. The patients could not remove the silicone stent once they were implanted; however, the stents were well-tolerated for a prolonged period in all patients. Conclusions: The incidence of fibrotic airway stenosis following RT in patients with ACC was relatively high. In addition, bronchoscopic intervention, including silicone airway stenting, was a safe and useful method for treating RT-induced fibrotic airway stenosis in patients with ACC. Purpose: Radiotherapy (RT) is usually administered to the central airway in patients with unresectable adenoid cystic carcinoma (ACC). The purpose of this study was to investigate the incidence, characteristics, and outcomes of bronchoscopic intervention in patients with ACC who developed fibrotic airway stenosis following RT. Methods and Materials: Forty-seven patients with ACC, who underwent RT of the tracheobronchial tree from 1995 to 2011, were reviewed retrospectively. Fibrotic airway stenoses were diagnosed using three-dimensional computed tomography, flexible bronchoscopy, or both. Results: Eleven (23%) of the 47 patients with ACC suffered fibrotic airway stenosis following RT and received bronchoscopic intervention. Bronchoscopic intervention provided both immediate symptomatic relief and improvement of lung function in all patients, and no procedure-related death or immediate major complication such as pneumomediastinum, pneumothorax, pneumonia, or massive bleeding was observed. Insertion of a straight silicone stent was required in 10 patients (91%), and 4 (36%) eventually received Y-shaped silicone stents. The patients could not remove the silicone stent once they were implanted; however, the stents were well-tolerated for a prolonged period in all patients. Conclusions: The incidence of fibrotic airway stenosis following RT in patients with ACC was relatively high. In addition, bronchoscopic intervention, including silicone airway stenting, was a safe and useful method for treating RT-induced fibrotic airway stenosis in patients with ACC.