Introduction: Lower vitamin D levels were associated with increased airway hyper-responsiveness and higher eosinophil counts and IgE levels, while higher vitamin D levels were associated with a lower hospitalization for asthma exacerbations. Objective: This study was conducted to evaluate whether atopy had relation with serum vitamin D level in Korean population. Methods: We analyzed data obtained as part of the fifth South Korean National Health and Nutrition Examination Survey (Korean NHANES V, 2010) of 2,338 Koreans. The correlation between serum 25-hydroxyvitamin D level and presence of atopy with results of specific IgE to Dermatophagoides farina (Df), cockroach and dog hair using Phamacia CAP system (Phamacia, Uppsala, Sweden) was analyzed. All estimates were calculated on the basis of the sampling weight. Results: Mean serum 25-hydroxyvitamin D level was 17.79±0.28 ng/mL. There was no difference in serum 25-hydroxyvitamin D level between populations with atopy and without atopy (17.97±0.32 vs. 17.63±0.35 ng/ml, P＞0.05). Despite of no difference in serum 25-hydroxyvitamin D level according to presence of atopy to Df or dog hair, population with specific IgE to cockroach had higher vitamin D level compared to those without specific IgE to cockroach (18.76±0.44 vs. 17.53±0.30 ng/ml, P=0.015). Conclusion: In the current study, atopy status was not related with serum vitamin D level in Korean.Introduction: Lower vitamin D levels were associated with increased airway hyper-responsiveness and higher eosinophil counts and IgE levels, while higher vitamin D levels were associated with a lower hospitalization for asthma exacerbations. Objective: This study was conducted to evaluate whether atopy had relation with serum vitamin D level in Korean population. Methods: We analyzed data obtained as part of the fifth South Korean National Health and Nutrition Examination Survey (Korean NHANES V, 2010) of 2,338 Koreans. The correlation between serum 25-hydroxyvitamin D level and presence of atopy with results of specific IgE to Dermatophagoides farina (Df), cockroach and dog hair using Phamacia CAP system (Phamacia, Uppsala, Sweden) was analyzed. All estimates were calculated on the basis of the sampling weight. Results: Mean serum 25-hydroxyvitamin D level was 17.79±0.28 ng/mL. There was no difference in serum 25-hydroxyvitamin D level between populations with atopy and without atopy (17.97±0.32 vs. 17.63±0.35 ng/ml, P＞0.05). Despite of no difference in serum 25-hydroxyvitamin D level according to presence of atopy to Df or dog hair, population with specific IgE to cockroach had higher vitamin D level compared to those without specific IgE to cockroach (18.76±0.44 vs. 17.53±0.30 ng/ml, P=0.015). Conclusion: In the current study, atopy status was not related with serum vitamin D level in Korean.