The number ofimplemented cancer screening per year of the National Cancer Screening Center was about 8,300. The cancer screening process was inefficient and a significant number of the result was notified to the customers within 15 days. In this study, the six sigma is introduced to improve there process and the problems. As a result, the monthly average cases of cancer screening are increased from 896 to 1,219. In addition, the rate of the notification within 15 days is increased from 66.1% to 98.8%. Moreover, the cancer screenings are activated through the guidelines and standardization of process of the support team. Therefore Customers` satisfaction is higher than before.