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Cyclospone의 NFATc1 발현 억제를 통한 모낭주기 조절(생장기모낭유도)에 대한 연구
Cyclosporine Stimulates the Expression of CDK4 through NFATc1 Suppression: Anagen Phase Hair InductionCyclospone의 NFATc1 발현 억제를 통한 모낭주기 조절(생장기모낭유도)에 대한 연구
이채영 ( Chae Young Lee ) , 고동엽 ( Dong Yeob Ko ) , 허은필 ( Eun Phil Heo ) , 김계정 ( Kea Jeong Kim ) , 송기훈 ( Ki Hoon Song ) , 김기호 ( Ki Ho Kim )
UCI I410-ECN-0102-2014-500-001914561

Background: Hair growth is spontaneously activated from quiescent bulge stem cells or is activated from precocious anagen. Upon spontaneous activation of hair growth or activation induced by nuclear factor of activated T cells c1 (NFATc1) inhibitors, NFATc1 expression is lost and cyclin dependent kinase (CDK4) repression is relieved. Objective: The purpose of this study was to investigate the mechanisms of cyclosporine as a hair cycle regulator in the treatment of Alopecia areata (AA). Methods: In this study, we planned to investigate the hair growing properties of cyclosporine in vitro conditions. Briefly, the effects of different concentrations of cyclosporine (200, 500, 1,000, 2,000 mmol) on the growth of cultured hair follicles were examined through the expression of NFATc1 and CDK4. Results: NFATc1 was downregulated and CDK4 expression was upregulated especially in the bulge areas, outer root sheath and hair bulb matrix cells as the concentration of cyclosporine increased. Conclusion: Cyclosporine induces CDK4 expression by NFATc1 suppression, which acts to relieve repressed CDK4, resulting in hair growth. In conclusion, cyclosporine is one of the candidates as a therapeutic agent for the treatment of hair loss. (Korean J Dermatol 2013;51(11):871∼877)

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