The purpose of this study was to investigate the effect of ego-resilience, school satisfaction and achievement motivation on career decision-making self-efficacy in university students. The subjects of this study were 357 university students in the area of Busan. The data were analyzed using descriptive statistics, correlation and multiple regression. The major findings of this study were as follows: First, responsibility which is sub-factor of achievement motivation, and ego-resilience influenced significantly goal selection which is sub-factor of career decision-making self-efficacy. Second, responsibility which is sub-factor of achievement motivation and ego-resilience had a significant influence on occupational information which is sub-factor of career decision-making self-efficacy. Third, task orientation which is sub-factor of achievement motivation, ego-resilience and school satisfaction were significant factors influencing problem solving of career decision-making self-efficacy. Forth, planning of career decision-making self-efficacy was significantly influenced by task orientation and responsibility of achievement motivation and ego-resilience. Fifth, responsibility, sub-factor of achievement motivation, and ego-resilience influenced significantly self-appraisal, sub-factor, of career decision-making self-efficacy. The results provided useful guidelines to understand the process of career development and the career goal for university students.