Background: The site of open thyroidectomy, anterior neck, is where postoperative scarring can cause patients` distress. Recently, both fractional laser and pulsed-dye laser have been reported to be effective and safe in prevention and improvement of a surgical scar. Objectives: The purpose of this study was to improve the appearance of scars, by laser intervention of the wound healing process. In this study, we evaluated the effect of non-ablative fractional laser and pulsed-dye laser on fresh thyroidectomy scars of patients. Methods: Patients were treated 3 times at 4-week interval with a follow-up visit at 6th month. A scar was divided into two for optional treatment. At every visit, questionnaire rating for evaluation of the scar and patient`s satisfaction was completed. Results: A total of 20 patients had completed the 6-month-period. The mean Vancouver Scar Scale score had improved from 8.38 to 5.31 with non-ablative fractional laser and from 8.25 to 5.38 with pulsed-dye laser, both of which statistically significant. But when comparing the two, there was no statistically significant difference. Conclusion: There is yet no universal consensus on optimal treatment of scar. Our data reveals that the two modalities brought statistically significant improvement to the scar respectively, but superiority of one to another couldn`t be proven. Further studies with larger number of subjects are needed to optimize which is the most effective.