Background: Measuring quality of life (QOL) is important in the evaluation of nonclinical aspects of disease, the discovery of functional and psychological limitations, and in choosing treatment in the initial phase of disease. Pemphigus is a rare but severe autoimmune disease, and it is clinically characterized by bullae and painful erosions of the skin and mucous membranes. Objectives: To study the impact of pemphigus on QOL in a large number of Korean patients. Methods: Sixty-six patients were assessed for QOL using the Dermatology Life Quality Index (DLQI) and for anxiety and depression using the General Health Questionnaire (GHQ). Spearman`s rank-order correlation, t-test, and ANOVA were used to identify the relationships between DLQI score and other clinical variables. Results: Pemphigus vulgaris and foliaceus significantly reduce patient QOL. The average DLQI score for all the patients was 10.18. In particular, the DLQI score highly correlated with disease severity and the treatment dose of steroid however, QOL was not affected by sex, age, subtype of pemphigus, duration of disease, or comorbidities. Forty-two percent of the patients showed a GHQ positive result, reflecting probable minor psychiatric nonpsychotic conditions, and the GHQ scores positively correlated to DLQI score. Conclusion: Pemphigus can significantly reduce the QOL of patients. The QOL of Korean pemphigus patients correlates with clinical severity.