Physical activity is planned activity to maintain and improve the factors of strength. Exercise can increase the energy consumption through the contraction of skeletal muscle and improve the cardiovascular problems and the metabolic risk factors by reforming blood sugar limitation level, blood lipids, weight and other metabolism. Accordingly, the perspective of this study is to identify that what effect GX program conducted by obese children will have on the change of nerve growth factor, cardiorespiratory fitness and metabolic risk factors. Twenty-eight subjects who hadn`t taken certain medicine or treatment were divided into two groups: training group (n=14, height: 140.83 ± 9.70, weight: 52.23 ± 7.22, %body-fat: 30.71 ± 1.71) and control group (n=14, height: 143.45 ± 5.83, weight: 55.66 ± 2.47, %body-fat: 30.03 ± 1.39). They were tested by body-composition, obesity, neuroplacidity, metabolic risk factors. Result as follow, first; there were significant differences between pre and post tests (p< .01). Also, there were significant differences in TG, HDL-C and glucose of metabolic risk factors among groups (p< .05) and there was no significant difference in blood pressure. Second; there was no statistically significant difference. Meanwhile, VO2max increased more than 2ml/kg/min in the group of GX program. Third; there were significant differences in %body-fat and HDL-C and most significant differences between pre and post-test in VO2max by over 2mL/kg. As the result of the research in which 12-week GX program was performed by growing children, there were positive effects on metabolic risk factors, cardiorespiratory fitness, and brain fitness. Also the performance applied music which focuses on children`s interest may positively affect improving children`s physical activity. Thus, it is considered that various applications should be continuously developed in public schools and community sports facilities.