The phenomenon of cohabitation is not new in the world and for that matter in Africa, although societies generally frown on its practice. It appears to have permeated every corner in society, displacing the original ideal for marriage. There was therefore the need to look at the challenges posed by cohabitation to the Seventh-day Adventist Church within the West and Central Africa region, and how it could be mitigated. Survey questionnaire was used to sample 36 ministers of the Church from the region. The collected data were analyzed via descriptive statistics, hierarchical factor analysis, and deductive reasoning. The study revealed that cohabitation is a threat to Seventh-day Adventism in the region. The main causes identified are as follows: (1) permissiveness of and encouragement from society, (2) unconverted hearts of some Church members, (3) lower moral standards, (4) unpreparedness of cohabitants for the commitments or responsibilities of marriage, (5) higher poverty levels, (6) influence by family and friends, (7) expensive doweries demanded by parents, (8) expensive nature of weddings, and (9) lower levels of education. With the implementation of the recommendations herein suggested, it is strongly believed that the problems identified may be surmounted. Local church leadership may be enlightened to deal with the problems in a practical and sustainable way.