Pantoraea species are motile, aerobic, non-fermentative, gram-negative bacilli. Pandoraea sp. has been isolated from the lungs and blood samples of cystic fibrosis patients, or from environmental samples. However, true pathogenic nature of the Pantoraea sputorum has not yet well known. To our knowledge, human infections caused by P. sputorum have not been reported in the world. We report the first case of P. sputorum bacteremia. An 83-year-old woman was admitted to our hospital because of fever with erythema and tenderness on the insertion site of perm catheter. We empirically started cefazolin. On hospital day 3, she became afebrile state and the redness and tenderness on perm catheter insertion site was made a full and rapid recovery. Six days later, blood culture via perm catheter yielded Comamonas testosterone which was susceptible to cefazolin. On the analysis of 16S ribosomal DNA sequences, P. sputorum was iedentified. She diagnosed perm catheter related blood stream infection due to P. sputorum. She received six days of intravenous antibiotics and was discharged home with oral antibiotics to complete a two-week course of antibiotics in total.