Purpose: We designed a prospective study to identify the impacts of antihypertensive therapy on dyssynchrony in patients with never-treated hypertension. Method: Sixty patients of never-treated hypertension (53.3% men, mean age 54.3±9.7 years) underwent echocardiographic evaluations of dyssynchrony at baseline and after 6 months of antihypertensive therapy. Measured parameters were as follows:(1) standard deviation (SD) of time from ECG Q to systolic peak velocity of 12 Left ventricular (LV) segments (ms, Ts-SD12) and maximum difference of time to systolic peak velocity among 12 LV segments (ms, Ts-Max) (systolic dyssynchrony); (2) SD of time from ECG Q to early diastolic peak velocity of 12 LV segments (ms, Te-SD12) and maximum difference of time to early diastolic velocity among 12 LV segments (ms, Te-Max) (diastolic dyssynchrony); (3) LV mass index (g/m2). Patients with systolic dyssynchrony (group 1, N=29) and without systolic dyssynchrony (group 2, N=31)at baseline were compared. Results: The changes of echocardiographic parameters were summarized in the table. In group 1 patients, systolic (Ts-SD12, Ts-Max) and diastolic (Te-Max) dyssynchrony, and LV mass index (LVMI) significantly improved after antihypertensive therapy. Conclusion: The present study confirmed that chronic antihypertensive treatment significantly reverses LV systolic dyssynchrony.