This research collected and organized the various materials about the economic effect of design and design strategies of major nations and cities. It aims to verify that aggressive investment in design is essential through demonstrating design as a core keyword to overcome the economic crisis in the era of worldwide recession. Namely, it confirms that design is a shortcut to overcome the economic crisis and a foundation for the new growth and economic take-off. There are many cases. England, receiver of the IMF loan at the end of 1970s, overcame the crisis through realization of the proposition, ``Design or Resign.`` With the leadership of Margaret Thatcher as a prime minister, England promoted Redesign project changing fundamental basis of the industry and restructuring enterprises and organizations. The great depression in 1930s was the period offering new anticipations to the designers. It also gave GM, who invested drastically to design, an opportunity to take the world market, while it gave Ford, who aimed at generally popular cars, a disappointment loosing the market. The more crisis it is, the more likely it is that design is important and emphasized. ``For revitalization of the economy, design is important`` by John Cotton Dana in 1928 and ``Design loves a Depression`` by Michael Channel in 2009 both stressed that design is important to economic recession. We developed the concept of DESIGNOMICS based on the idea that ``Design becomes more important in times of depression.`` Designomics is a compound word of design and economy emphasizing the economic aftereffect of design. The primary point of view of Designomics is that design has a great effect to economy, and especially in the period of depression there are many cases overcoming the economic crisis relying on design. Therefore, Designomics is used to highlight the necessity of design management and the significance of strategic approach as well as regular and continuous investment. Through the analysis of the historical and modern meaning of Designomics and the strategies of each country and city, we confirmed the great ripple effect of design and the necessity of design management. For example, an average period and expenses for the development of design can be reduced from 1/10 up to 1/20 comparing to that of technology. With that less effort, however, the research on the English enterprises shows that the company with more emphasis on design has the higher and stabler stock prices. It tells us that design facilitates the value and stability of the enterprise, and serves as a momentum to innovate the enterprise. Many companies practically channel to design based enterprise through continuous innovation of merchandises, production, management, organization, image, and etc. by design. It is same with the nation and the city. England, Japan, and USA all put a premium on design. Also rising nations are trying to control the world market through design innovation. Many cities develops symbol, revitalize underdeveloped areas, change the life of citizens, and nurturing art, contents as well as tourist by various design projects. In that Designomics of Seoul function as a principal strategy to overcome the recession by getting over the limit and at the same time building growth power of the future. To the current Seoul with the level of urban infrastructure in 10 thousand dollars in spite of the national income close to 20 thousand dollars, the recession can be the chance. Utilizing the recession, Seoul can channel to sustainably growing city by promoting the various design management improving the urban infrastructure and creating the brand and image of Seoul. Without the effort, Seoul will pay dear for the deteriorated urban environment. In that point, Designomics of Seoul is not an extravagant project wasting the taxes, but a project securing sustainable growth potentiality overcoming the worldwide recession.