18.97.14.83
18.97.14.83
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백단향추출물의 항산화, 항혈소판 응집 및 혈전 용해능에 관한 연구
Preventive Effects of Santalum album L. Extracts on Oxidation, Platelet Aggregation and Thrombosis
송영위 ( Yung Wei Sung ) , 이지현 ( Ji Hyun Lee ) , 송규주 ( Kyoo Ju Song ) , 구병수 ( Byung Soo Koo ) , 김근우 ( Geun Woo Kim )
UCI I410-ECN-0102-2012-510-003215076
* This article is free of use.

Objectives : To evaluate the in vitro scavenging activity, inhibitory effect of LDL oxidation of pro-oxidant reactive species, anti-platelet aggregative effects and anti-thrombosis effects in response to treatment with SA using various screening methods including biological and non-biological oxidants. Methods : The antioxidant activity concerning extract from SA was studied with in vitro methods by measuring the antioxidant activity by TEAC, measuring the scavenging effects on reactive oxygen species (ROS) [superoxide anion, hydroxyl radical] and on reactive nitrogen species (RNS) [nitric oxide and peroxynitrite] as well as measuring the inhibitory effect on Cu2+-induced human LDL oxidation and the inhibitory effect on thrombin-induced platelet aggregation and thrombosis. Results : SA extracts were found to have a potent scavenging activity regarding oxidative stress as well as an inhibitory effect towards LDL oxidation, platelet aggregation, and thrombosis. Conclusions : The SA extracts have anti-oxidative and anti-atherosclerotic effects in vitro system, which can be used for developing pharmaceutical drugs against oxidative stress and atherosclerosis.

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