The purpose of this study was to investigate the variation of regional skin temperature with thermography during exercise. Seven men completed 82-min trials which consisted of rest, exercise of V02 max 60% and recovery period at 30±o.5°C and 60±5%RH. Changes in skin temperature due to physical activity varied, depending region of the body. The skin temperature of the chest was significantly lowered and that of the back was significantly increased after exercise period(p<0.05). There were significant negative relationship between the skin temperature of the chest and thermal comfort sensation, and positive relationship between skin temperature of the back and thermal comfort sensation(p<0.05). It would be better to keep the chest warm, and the back cool during exercise. The skin temperature changed differently on body site due to exercise, and it was influenced by blood flow, sweating and air movement This study would be meaningful in that the change of regional skin temperature during exercise was investigated consecutively with thermography. In further study, it would be more realistic to measure physiological response with functional sportswear which applies different functional fabric based on skin temperature.