The surface characteristics and performance of PTFE (polytetrafluoroethylene) hollow fiber membranes have been systematically investigated at lab- and pilot-scale to assess their application to membrane-bioreactor, particularly for integrating wastewater reclamation and rainwater harvesting. The PTFE membrane expressed some surface features, such as hydrophobicity, which might enhance membrane fouling. However, lab-scale performance and cleaning experiments under various conditions demonstrated that the PTFE membrane could produce the desirable water flux with good cleaning efficiency, implying easy operation and maintenance due to superior chemical resistance of PTFE membranes. Most of effluent water qualities were met with Korean standard for discharge and reuse, except color. Color level was further reduced by blending with rainwater at 75:25 ratio. Based on the lab-scale experimental results, the pilot plant was designed and operated. Pilot operation clearly showed sTable performance with satisfactory water quality, suggesting that PTFE membrane could be applied for decentralized MBR integrated with rainwater use.