Objective: To investigate effects of herbal preparations formulated(Gihyeolgwanjeolbang-A, CWS-A) on complete Freund`s adjuvant (CFA)-induced arthritis in rats. Method: Arthritis was induced by injecting CFA subcutaneously into the left knee joint and paw, and the herbal preparations formulated(CWS-AⅠ, 82.3 mg/kg;CWS-AⅡ, 164.6 mg/kg) was administered orally (i.g.) for 10 consecutive days beginning on day 10 after the injection. External shape, paw edema, inflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin-1 beta (IL-1beta), and histological observation were assessed. Result: In swelling of the paw, CWS-AⅠ and CWS-AⅡ group in 15 days and 20 days were significantly reduced compared to controls. In serum ALT, CWS-AⅠ and CWS-AⅡ group were significantly reduced compared to controls. In TNF-α, CWS-AⅠ and CWS-AⅡ group were a tendency reduced compared to controls. In HGB, HCT, MCHC of erythrocytes, CWS-AⅡ group was increased compared to controls. In histological observations, CWS-AⅡ group was observed synoviocytes more than control group and was observed proteoglycans in the deep layers. Conclusion: The data suggest that CWS-A significant anti-arthritic effects that may be mediated by suppressing inflammatory parameters.