Purpose: To investigate relation between Heart rate variability(HRV) and Kupperman`s index. Methods: From 2004, 3, 15 to 2004, 4, 10, a total 18 female patients(age 40-61) was recruited. but 2 patients was excluded. one was under hormone raplacement therapy, the other was under drug treatment. We measured patient`s HRV by SA-2000E(Medicore Co., Ltd., Korea), and they fulfilled kupperman`s index and qustionnaire. Results: The mean age of patient was 50.13±5.78 years. 6 of 16 patients was menopause, 12 of 16 patients had menstruation. half of 16 patients had a understanding about climacteric syndrome. Investigating relation between HRV and kupperman`s index, kupperman`s index had positive correlation with heart rate significantly. Kupperman`s index had negative correlation with SDNN significantly. Kupperman`s index had negative correlation with RMS-SD significantly. Conclusion: In this study, we presented relation between HRV and kupperman`s index. Furthermore, large scale study is required.