Sibutramine is originally known as an anti-obesity drug. The biological activities of sibutramine are various, such as depression, parkinson`s disease, diabetes mellitus, and obesity. Sibutramine maleate was synthesized from sibutramine free base which also synthesized by 4 steps reactions. The intermediates to synthesize sibutramine are 1-(4-chlorophenyl)-1-cycloisobutylcarbonitrile, 1-isobutyryl-1-(4-chlorophenyl)cyclobutane, and N-formyl-1-[1-(4- chlorophenyl)cyclobutyl]isobutylamine. The synthesized sibutramine maleaste are assayed by UV/visible spectroscopy and HPLC with UV/visible detector. The purity of the synthesized sibutramine maleate are determined from the HPLC data.