Objective: This research investigates the effect of the CMT and MCMT on Alzheimer`s disease. Methods : The effects of the CMT and MCMT extract on (1) amyloid precursor proteins(APP), acetylcholinesterase(AChE) mRNA of PC-12 cells treated with CT-105; (2) the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of IL-1β, TNF-α, MDA, GFAP, CD68 abd CD11b; (5) the infarction area of the hippocampus in Alzheimer`s diseased mice induced with βA were investigated. Results : 1. The CMT and MCMT extract suppressed the expression of APP, AChE, and mRNA in PC-12 cells treated with CT-105. 2. The CMT and MCMT extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 3. For the CMT and MCMT extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer`s disease induced by βA in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 4. The CMT and MCMT extract suppressed the over-expression of IL-1β, TNF-α, MDA, GFAP, CD68 abd CD11bCD68/GFAP, in the mice with Alzheimer`s disease induced by βA. 5. The CMT and MCMT extract reduced the infarction area of hippocampus with Alzheimer`s disease induced by βA. 6. The MCMT showed more excellent effects than CMT in the every experiments except PC-12 cells. Conclusions : These results suggest that the CMT and MCMT extract may be effective for the prevention and treatment of Alzheimer`s disease. Investigation into the clinical use of the CMT and MCMT extract for Alzheimer`s disease is suggested for future research.