This study investigated the effect of introducing advanced science contents into the science curriculum 10th grade on students` interest in science. Four classes of the 10th grade were selected from a co-ed high school located in the city of Seoul. Among them, each two classes were assigned as a control group and treatment group, respectively. Students in each group were divided into three groups according to their previous science achievement. The treatment group was taught with materials consisting of advanced science content that was associated with the ``Reaction Rates``, ``Environment`` and ``Inquiry of Science`` section of the curriculum. Before and after being taught over a six-week period, students` interest in science and science class were measured. The data showed that there was a significant correlation between the instruction and students` previous science achievement in the ``interest in science``(p<.01). There was a significant difference between the two groups in the ``interest in science class`` irrespective of their prior science achievement (p<.05). The data showed that the introduction of advanced science content into the science curriculum had considerable effect on increasing students` interest in science and science class. Moreover, many students expected more opportunities to learn advanced science content associated with the science curriculum.