Although it has been reported that extracts of Centella asiatica (C. asiatica), a pharmacological plant containing various pentacyclic triterpenes, exert wound healing and collagen synthesis in skin cells, there are only a few clinical studies of the effect of C. asiatica extracts on human skin. In this study we have examined the anti-wrinkle and lifting effects of cosmetics containing extracts of C. asiatica on eleven healthy subjects. Compared to before and after treatment, the visual grade of wrinkle was improved 3.05% after 4 weeks. Ra, Rz and Rp parameters were significantly reduced after 4 weeks (p<0.05). The dermal density was significantly improved after 2 and 4 weeks (p<0.05). Skin sagging was significantly improved immediately after using the product, after 2 and 4 weeks. Adverse reactions of subjects were not observed during the course of the study. These observations indicate that C. asiatica extracts have the antiwrinkle and lifting effects on human skin and can be usefully applied to the anti-aging cosmetic industry.