Rhapontici Radix is in use in oriental medicine. Oriental medical doctors use Rhapontici Radix for clearing away heat and eliminating toxin(淸熱解毒), etc. We investigated toxicity, poisoning symptoms, poisoning treatment and prevention against poisoning of Rhapontici Radix. The results were summarized as follows: 1. The main ingredients of poisoning from Echinops Latifolii Radix(禹州漏蘆) are echinopsine, etc. The ingredients of poisoning from Rhapontici Radix mainly cause stimulating symptoms on central nervous system, etc. 2. The representative methods of poisoning treatment are symptomatic treatment, etc. 3. In order to prevent against poisoning of Rhapontici Radix, the patients should keep usage, dosage and notes.