저자들은 쿠싱증후군의 징후와 저칼륨혈증의 증상을 보인 환자에서 코르티졸, 안드로겐, 알도스테론 증가를 보인 부신피질암을 진단하였다. 부신절제술 후 3기의 부신피질암으로 진단되고 현재 mitotane 보조 화학요법으로 추적 관찰하고 있는 증례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

Primary adrenocortical carcinoma is a rare tumor, and is characterized by a peri-tumor mass effect and hormone excess signs. Adrenocortical carcinoma most commonly secretes cortisol, but tumors that secrete other adrenal hormones (aldosterone, androgen) are rare. Herein, we report the case of a 70-year-old woman with cortisol, androgen, and aldosterone-secreting adrenal carcinoma. The patient complained of generalized weakness, moon face, and central obesity. On laboratory examination, hypokalemia and metabolic alkalosis was detected. On the hormone test, cortisol, DHEA-S, and aldosterone were all increased. Abdominal CT showed a large right adrenal mass. She underwent right adrenalectomy and the histology revealed the presence of an adrenocortical carcinoma. After adrenalectomy, the patient was treated with hydrocortisone and mitotane. (Endocrinol Metab 26:239-242, 2011)