Demodex folliculorum is a common mite of the pilosebaceous unit. Usually demodex infestation does not lead to the manifestation of pathologic skin diseases. But, in specific environments such as immunologic deficiency, they can proliferate and provoke cutaneous lesions. A 58-year-old patient presented with multiple, erythematous, annular-shaped plaques on the nose and right cheek. He had a 9-year history of Sjogren disease and she was treated with oral steroids and methotrexate. We found numerous Demodex folliculorum mites through a KOH microscopic examination and histologic examination of the right cheek. Biopsy resultd revealed that Demodex folliculorum mites were contained in the dilated follicular infundibulum. We diagnosed this case as an unusual manifestation of a Demodex infestation in a patient with Sjogren disease. We report an annular plaque-forming demodicidosis treated successfully with metronidazole. (Korean J Dermatol 2011; 49(2):188~190)