Serum proteins of Korean native dogs (Gyeongju DongGyeong dogs) was analyzed by capillary electrophoresis system. Electrophoretic patterns showed six fractions. Total serum protein and ratio of albumin to globulin were 5.99±0.83 (g/dl) and 1.41±0.29 (g/dl) in DongGyeong dogs. Relative percentages of total serum albumin and α-1, α-2, β-1, β-2, γ-globulin fraction were 57.94±5.43, 3.15±2.30, 7.49±4.09, 9.43 ±3.50, 7.63±5.70, and 14.36±7.63, respectively. It was observed that β-globulin was higher than other fractions. The most striking alternation with age was founded in the γ-fractions. Also, it was observed that ratios of albumin to globulin in DongGyeong dogs were higher than on other dogs.