This study was carried out to determination of carbadox and olaquindox residues in swine tissues by MSPD(matrix solid phase disperse)method. The results obtained were as follows; 1. Optimal wavelengths of UV for carbadox and olaquindox were 310 and 370nm, respectively. 2. Ethyl acetate-Acetonitrile(8:2) was found to be adequate as extractant in this method. 3. The average overall recovery of carbadox at the 0.01, 0.05, and 1.0PPM spike levels was 89.2% and that of olaquindox was 89.9%, and the detection limits were 0.5ng for carbadox and olaquindox.